8TQ0

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with (R)-Lipoic Acid

8TQ0 の概要

• エントリーDOI: 10.2210/pdb8tq0/pdb
• 分子名称: Hdac6 protein, DIHYDROLIPOIC ACID, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81274.86

構造登録者

Watson, P.R.,Christianson, D.W. (登録日: 2023-08-06, 公開日: 2023-09-20, 最終更新日: 2024-04-03)

• 主引用文献: Watson, P.R.,Stollmaier, J.G.,Christianson, D.W.; Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism.; J.Biol.Chem., 299:105228-105228, 2023; PubMed: 37703993; DOI: 10.1016/j.jbc.2023.105228

実験手法

X-RAY DIFFRACTION (2.4 Å)