8TPV
Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
8TPV の概要
エントリーDOI | 10.2210/pdb8tpv/pdb |
分子名称 | Hypoxanthine-guanine phosphoribosyltransferase, (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
機能のキーワード | inhibitor, prolinol, complex, parasitic drug lead, transferase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 100236.64 |
構造登録者 | |
主引用文献 | Keough, D.T.,Petrova, M.,King, G.,Kratochvil, M.,Pohl, R.,Dolezelova, E.,Zikova, A.,Guddat, L.W.,Rejman, D. Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. J.Med.Chem., 67:7158-7175, 2024 Cited by PubMed: 38651522DOI: 10.1021/acs.jmedchem.4c00021 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.27 Å) |
構造検証レポート
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