8TPB
Synthesis, X-Ray Crystallographic and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease
8TPB の概要
エントリーDOI | 10.2210/pdb8tpb/pdb |
分子名称 | Non-structural protein 7, N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)-2-chloroacetamide (3 entities in total) |
機能のキーワード | non-peptidic inhibitors, inhibitors, sars-cov-2, main protease, mpro, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
由来する生物種 | Severe acute respiratory syndrome coronavirus 2 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 68226.75 |
構造登録者 | |
主引用文献 | Ashraf-Uz-Zaman, M.,Chua, T.K.,Li, X.,Yao, Y.,Moku, B.K.,Mishra, C.B.,Avadhanula, V.,Piedra, P.A.,Song, Y. Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease. Acs Infect Dis., 10:715-731, 2024 Cited by PubMed: 38192109DOI: 10.1021/acsinfecdis.3c00565 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.88 Å) |
構造検証レポート
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