8TMR
Crystal structure of KPC-44 carbapenemase complexed with avibactam
Summary for 8TMR
| Entry DOI | 10.2210/pdb8tmr/pdb |
| Related | 8TJM |
| Descriptor | beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, PHOSPHATE ION, ... (5 entities in total) |
| Functional Keywords | kpc carbapenemase, ceftazidime-avibactam resistance, hydrolase |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 30522.11 |
| Authors | Sun, Z.,Palzkill, T.,Hu, L.,Lin, H.,Sankaran, B.,Wang, J.,Prasad, B. (deposition date: 2023-07-30, release date: 2023-12-06, Last modification date: 2023-12-27) |
| Primary citation | Sun, Z.,Lin, H.,Hu, L.,Neetu, N.,Sankaran, B.,Wang, J.,Prasad, B.V.V.,Palzkill, T. Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300:105493-105493, 2023 Cited by PubMed: 38000656DOI: 10.1016/j.jbc.2023.105493 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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