8TLY

Human ASCC1 Phosphodiesterase/Ligase Domain

Summary for 8TLY

Entry DOI	10.2210/pdb8tly/pdb
Descriptor	Activating signal cointegrator 1 complex subunit 1 (2 entities in total)
Functional Keywords	alkylation response, rna damage, kh domain, phosphoesterase domain, rna ligase domain, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	56249.79
Authors	Tsutakawa, S.E.,Tainer, J.A.,Arvai, A.S.,Thapar, R. (deposition date: 2023-07-27, release date: 2024-07-10)
Primary citation	Chinnam, N.B.,Thapar, R.,Arvai, A.S.,Sarker, A.H.,Soll, J.M.,Paul, T.,Syed, A.,Rosenberg, D.J.,Hammel, M.,Bacolla, A.,Katsonis, P.,Asthana, A.,Tsai, M.S.,Ivanov, I.,Lichtarge, O.,Silverman, R.H.,Mosammaparast, N.,Tsutakawa, S.E.,Tainer, J.A. ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J.Biol.Chem., 300:107368-107368, 2024 Cited by PubMed: 38750793 DOI: 10.1016/j.jbc.2024.107368 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation