8TLY

Human ASCC1 Phosphodiesterase/Ligase Domain

8TLY の概要

• エントリーDOI: 10.2210/pdb8tly/pdb
• 分子名称: Activating signal cointegrator 1 complex subunit 1 (2 entities in total)
• 機能のキーワード: alkylation response, rna damage, kh domain, phosphoesterase domain, rna ligase domain, rna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56249.79

構造登録者

Tsutakawa, S.E.,Tainer, J.A.,Arvai, A.S.,Thapar, R. (登録日: 2023-07-27, 公開日: 2024-07-10)

• 主引用文献: Chinnam, N.B.,Thapar, R.,Arvai, A.S.,Sarker, A.H.,Soll, J.M.,Paul, T.,Syed, A.,Rosenberg, D.J.,Hammel, M.,Bacolla, A.,Katsonis, P.,Asthana, A.,Tsai, M.S.,Ivanov, I.,Lichtarge, O.,Silverman, R.H.,Mosammaparast, N.,Tsutakawa, S.E.,Tainer, J.A.; ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase.; J.Biol.Chem., 300:107368-107368, 2024; PubMed: 38750793; DOI: 10.1016/j.jbc.2024.107368

実験手法

X-RAY DIFFRACTION (2.8 Å)