8TLC
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor
Summary for 8TLC
Entry DOI | 10.2210/pdb8tlc/pdb |
Descriptor | Serine hydroxymethyltransferase, mitochondrial, N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid (3 entities in total) |
Functional Keywords | shmt2, tetramer, glycine synthesis, inhibitor, polyglutamate, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 110399.77 |
Authors | |
Primary citation | Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E. Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024 Cited by PubMed: 38324671DOI: 10.1021/acs.biochem.3c00613 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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