8TLC
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor
8TLC の概要
エントリーDOI | 10.2210/pdb8tlc/pdb |
分子名称 | Serine hydroxymethyltransferase, mitochondrial, N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid (3 entities in total) |
機能のキーワード | shmt2, tetramer, glycine synthesis, inhibitor, polyglutamate, transferase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 110399.77 |
構造登録者 | |
主引用文献 | Katinas, J.M.,Nayeen, M.J.,Schneider, M.,Shah, K.,Fifer, A.N.,Klapper, L.M.,Sharma, A.,Thalluri, K.,Van Nieuwenhze, M.S.,Hou, Z.,Gangjee, A.,Matherly, L.H.,Dann 3rd, C.E. Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024 Cited by PubMed: 38324671DOI: 10.1021/acs.biochem.3c00613 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.72 Å) |
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