8TK5
HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES
Summary for 8TK5
Entry DOI | 10.2210/pdb8tk5/pdb |
Descriptor | Dual specificity protein phosphatase 3, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, TETRAETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | protein dual-specificity phosphatase, vhr, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 41819.51 |
Authors | Aleshin, A.E.,Wu, J.,Lambert, L.J.,Cosford, N.D.P.,Tautz, L. (deposition date: 2023-07-25, release date: 2024-08-14) |
Primary citation | Wu, J.,Aleshin, A.E.,Lambert, L.J.,Cosford, N.D.P.,Tautz, L. Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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