8TJL

EGFR kinase in complex with pyrazolopyrimidine covalent inhibitor

8TJL の概要

• エントリーDOI: 10.2210/pdb8tjl/pdb
• 分子名称: Epidermal growth factor receptor, 1-{3-[(4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one (3 entities in total)
• 機能のキーワード: egfr, kinase, covalent inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37954.82

構造登録者

Beyett, T.S.,Eck, M.J. (登録日: 2023-07-22, 公開日: 2024-02-14, 最終更新日: 2024-03-06)

• 主引用文献: Li, Z.,Lu, W.,Beyett, T.S.,Ficarro, S.B.,Jiang, J.,Tse, J.,Kim, A.Y.,Marto, J.A.,Che, J.,Janne, P.A.,Eck, M.J.,Zhang, T.,Gray, N.S.; ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.; J.Med.Chem., 67:2837-2848, 2024; PubMed: 38300264; DOI: 10.1021/acs.jmedchem.3c01891

実験手法