8TI4
monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface
Summary for 8TI4
Entry DOI | 10.2210/pdb8ti4/pdb |
Descriptor | IgG1 Fab heavy chain, mutated to promote correct pairing, IgG1 Fab light chain, mutated for better pairing with cognate heavy chain, GLYCEROL, ... (4 entities in total) |
Functional Keywords | igg1 antigen binding fragment, mutated, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 47050.46 |
Authors | |
Primary citation | Bagert, J.D.,Oganesyan, V.,Chiang, C.I.,Iannotti, M.,Lin, J.,Yang, C.,Payne, S.,McMahon, W.,Edwards, S.,Dippel, A.,Hutchinson, M.,Huang, F.,Aleti, V.,Niu, C.,Qian, C.,Denham, J.,Ferreira, S.,Pradhan, P.,Penney, M.,Wang, C.,Liu, W.,Walseng, E.,Mazor, Y. Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface. Mabs, 15:2273449-2273449, 2023 Cited by PubMed: 37930310DOI: 10.1080/19420862.2023.2273449 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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