8TI4

monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-CL interface

8TI4 の概要

• エントリーDOI: 10.2210/pdb8ti4/pdb
• 分子名称: IgG1 Fab heavy chain, mutated to promote correct pairing, IgG1 Fab light chain, mutated for better pairing with cognate heavy chain, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: igg1 antigen binding fragment, mutated, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47050.46

構造登録者

Oganesyan, V.Y.,van Dyk, N.,Mazor, Y. (登録日: 2023-07-19, 公開日: 2023-11-22)

• 主引用文献: Bagert, J.D.,Oganesyan, V.,Chiang, C.I.,Iannotti, M.,Lin, J.,Yang, C.,Payne, S.,McMahon, W.,Edwards, S.,Dippel, A.,Hutchinson, M.,Huang, F.,Aleti, V.,Niu, C.,Qian, C.,Denham, J.,Ferreira, S.,Pradhan, P.,Penney, M.,Wang, C.,Liu, W.,Walseng, E.,Mazor, Y.; Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C lambda interface.; Mabs, 15:2273449-2273449, 2023; PubMed: 37930310; DOI: 10.1080/19420862.2023.2273449

実験手法

X-RAY DIFFRACTION (2.1 Å)