8THL
Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein
Summary for 8THL
Entry DOI | 10.2210/pdb8thl/pdb |
EMDB information | 41268 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | alpha-1a-adrenergic receptor, epinephrine, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 160701.43 |
Authors | Su, M.,Huang, X.Y. (deposition date: 2023-07-17, release date: 2023-08-16, Last modification date: 2024-05-01) |
Primary citation | Su, M.,Wang, J.,Xiang, G.,Do, H.N.,Levitz, J.,Miao, Y.,Huang, X.Y. Structural basis of agonist specificity of alpha 1A -adrenergic receptor. Nat Commun, 14:4819-4819, 2023 Cited by PubMed: 37563160DOI: 10.1038/s41467-023-40524-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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