8THL

Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein

8THL の概要

• エントリーDOI: 10.2210/pdb8thl/pdb
• EMDBエントリー: 41268
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: alpha-1a-adrenergic receptor, epinephrine, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 160701.43

構造登録者

Su, M.,Huang, X.Y. (登録日: 2023-07-17, 公開日: 2023-08-16, 最終更新日: 2024-05-01)

• 主引用文献: Su, M.,Wang, J.,Xiang, G.,Do, H.N.,Levitz, J.,Miao, Y.,Huang, X.Y.; Structural basis of agonist specificity of alpha 1A -adrenergic receptor.; Nat Commun, 14:4819-4819, 2023; PubMed: 37563160; DOI: 10.1038/s41467-023-40524-2

実験手法

ELECTRON MICROSCOPY (3.1 Å)