8THG
Cryo-EM structure of Nav1.7 with RLZ
Summary for 8THG
Entry DOI | 10.2210/pdb8thg/pdb |
EMDB information | 41261 |
Descriptor | Sodium channel protein type 9 subunit alpha, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sodium channel subunit beta-1, ... (11 entities in total) |
Functional Keywords | cryo-em, sodium channel, vgsc, nav1.7, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 284425.08 |
Authors | |
Primary citation | Huang, J.,Fan, X.,Jin, X.,Teng, L.,Yan, N. Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120:e2309773120-e2309773120, 2023 Cited by PubMed: 37782796DOI: 10.1073/pnas.2309773120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
Download full validation report