8TGU

Cryo-EM structure of BG505 SOSIP trimer purified via Galanthus nivalis lectin chromatography

Summary for 8TGU

• Entry DOI: 10.2210/pdb8tgu/pdb
• EMDB information: 41244
• Descriptor: HIV-1 Envelope glycoprotein BG505 SOSIP, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hiv-1, glycoprotein, lectin, trimer, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 3
• Total formula weight: 233006.49

Authors

Parsons, R.J.,Pothula, K.,Acharya, P. (deposition date: 2023-07-13, release date: 2024-08-28, Last modification date: 2024-09-04)

• Primary citation: Parthasarathy, D.,Pothula, K.R.,Ratnapriya, S.,Cervera Benet, H.,Parsons, R.,Huang, X.,Sammour, S.,Janowska, K.,Harris, M.,Sodroski, J.,Acharya, P.,Herschhorn, A.; Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies.; Nat Commun, 15:7334-7334, 2024; PubMed: 39187497; DOI: 10.1038/s41467-024-51656-4

Experimental method

ELECTRON MICROSCOPY (3.8 Å)