8TFT
Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3
Summary for 8TFT
Entry DOI | 10.2210/pdb8tft/pdb |
Descriptor | O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, T-cell immunoglobulin mucin receptor 3, ... (5 entities in total) |
Functional Keywords | fragment antigen binding, antibody, t-cell immunoglobulin mucin receptor 3 (tim-3), igv type domain, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 118768.57 |
Authors | Oganesyan, V.Y.,van Dyk, N.,Mazor, Y.,Yang, C. (deposition date: 2023-07-11, release date: 2024-08-28) |
Primary citation | Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,Moynihan, J.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.A.,Pollizzi, K.N. Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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