8TFQ

Fab from C10-S66K antibody in complex with fentanyl

Summary for 8TFQ

Entry DOI	10.2210/pdb8tfq/pdb
Descriptor	Light chain from Fab of C10_S66K antibody, Heavy chain from Fab of C10_S66K antibody, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide, ... (4 entities in total)
Functional Keywords	antibody, fentanyl, opioid., immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	94133.41
Authors	Pholcharee, T.,Wilson, I.A. (deposition date: 2023-07-11, release date: 2023-08-16, Last modification date: 2023-08-23)
Primary citation	Eubanks, L.M.,Pholcharee, T.,Oyen, D.,Natori, Y.,Zhou, B.,Wilson, I.A.,Janda, K.D. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. Acs Chem Neurosci, 14:2849-2856, 2023 Cited by PubMed: 37534714 DOI: 10.1021/acschemneuro.3c00455 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation