8TFN

Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR

8TFN の概要

• エントリーDOI: 10.2210/pdb8tfn/pdb
• 分子名称: TRAV12-3, TRBV6-5, Anti-TCRVb6-5 Fab heavy chain, ... (5 entities in total)
• 機能のキーワード: tcr, anti-tcr, trbv12-3, trbv6-5, complex structure, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 97122.98

構造登録者

Katragadda, M.,Servatalab, R.,Wirth, J. (登録日: 2023-07-11, 公開日: 2023-11-08, 最終更新日: 2024-10-23)

主引用文献

Vantourout, P.,Eum, J.,Conde Poole, M.,Hayday, T.S.,Laing, A.G.,Hussain, K.,Nuamah, R.,Kannambath, S.,Moisan, J.,Stoop, A.,Battaglia, S.,Servattalab, R.,Hsu, J.,Bayliffe, A.,Katragadda, M.,Hayday, A.C.
Innate TCR beta-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials.
Sci Adv, 9:eadj6174-eadj6174, 2023

PubMed Abstract: Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly mediated by complementarity-determining region 3 motifs created by quasi-random T cell receptor (TCR) gene rearrangements, with diversity being highest for TCRγδ. Nonetheless, TCRγδ also displays nonclonotypic innate responsiveness following engagement of germline-encoded Vγ-specific residues by butyrophilin (BTN) or BTN-like (BTNL) proteins that uniquely mediate γδ T cell subset selection. We now report that nonclonotypic TCR engagement likewise induces distinct phenotypes in TCRαβ cells. Specifically, antibodies to germline-encoded human TCRVβ motifs consistently activated naïve or memory T cells toward core states distinct from those induced by anti-CD3 or superantigens and from others commonly reported. Those states combined selective proliferation and effector function with activation-induced inhibitory receptors and memory differentiation. Thus, nonclonotypic TCRVβ targeting broadens our perspectives on human T cell response modes and might offer ways to induce clinically beneficial phenotypes in defined T cell subsets.

PubMed: 38055824
DOI: 10.1126/sciadv.adj6174

実験手法

X-RAY DIFFRACTION (2.54 Å)