8TDR
Crystal structure of the methyltransferase domain of DNMT3A homotetramer
Summary for 8TDR
Entry DOI | 10.2210/pdb8tdr/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE (2 entities in total) |
Functional Keywords | dna methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 264416.40 |
Authors | Lu, J.W.,Song, J.K. (deposition date: 2023-07-04, release date: 2024-03-13, Last modification date: 2024-09-25) |
Primary citation | Lu, J.,Guo, Y.,Yin, J.,Chen, J.,Wang, Y.,Wang, G.G.,Song, J. Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nat Commun, 15:3111-3111, 2024 Cited by PubMed: 38600075DOI: 10.1038/s41467-024-47398-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.32 Å) |
Structure validation
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