8TCE

Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871

Summary for 8TCE

Entry DOI	10.2210/pdb8tce/pdb
Descriptor	Apolipoprotein(a), (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid (3 entities in total)
Functional Keywords	complex, inhibitor, ldl, lipid binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	22234.73
Authors	Hendle, J.,Weichert, K.,Sauder, J.M. (deposition date: 2023-06-30, release date: 2024-05-08, Last modification date: 2024-06-19)
Primary citation	Diaz, N.,Perez, C.,Escribano, A.M.,Sanz, G.,Priego, J.,Lafuente, C.,Barberis, M.,Calle, L.,Espinosa, J.F.,Priest, B.T.,Zhang, H.Y.,Nosie, A.K.,Haas, J.V.,Cannady, E.,Borel, A.,Schultze, A.E.,Sauder, J.M.,Hendle, J.,Weichert, K.,Nicholls, S.J.,Michael, L.F. Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629:945-950, 2024 Cited by PubMed: 38720069 DOI: 10.1038/s41586-024-07387-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.07 Å)

Structure validation