8TC9

Human asparaginyl-tRNA synthetase bound to OSM-S-106

8TC9 の概要

• エントリーDOI: 10.2210/pdb8tc9/pdb
• 分子名称: Asparagine--tRNA ligase, cytoplasmic, N~1~-[(3M)-3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzene-1-sulfonyl]-L-aspartamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: enzyme, ligase, synthase, drug target
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 257380.72

構造登録者

Dogovski, C.,Metcalfe, R.D.,Xie, S.C.,Morton, C.J.,Tilley, L.,Griffin, M.D.W. (登録日: 2023-06-30, 公開日: 2024-02-07, 最終更新日: 2024-02-14)

• 主引用文献: Xie, S.C.,Wang, Y.,Morton, C.J.,Metcalfe, R.D.,Dogovski, C.,Pasaje, C.F.A.,Dunn, E.,Luth, M.R.,Kumpornsin, K.,Istvan, E.S.,Park, J.S.,Fairhurst, K.J.,Ketprasit, N.,Yeo, T.,Yildirim, O.,Bhebhe, M.N.,Klug, D.M.,Rutledge, P.J.,Godoy, L.C.,Dey, S.,De Souza, M.L.,Siqueira-Neto, J.L.,Du, Y.,Puhalovich, T.,Amini, M.,Shami, G.,Loesbanluechai, D.,Nie, S.,Williamson, N.,Jana, G.P.,Maity, B.C.,Thomson, P.,Foley, T.,Tan, D.S.,Niles, J.C.,Han, B.W.,Goldberg, D.E.,Burrows, J.,Fidock, D.A.,Lee, M.C.S.,Winzeler, E.A.,Griffin, M.D.W.,Todd, M.H.,Tilley, L.; Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.; Nat Commun, 15:937-937, 2024; PubMed: 38297033; DOI: 10.1038/s41467-024-45224-z

実験手法

X-RAY DIFFRACTION (2 Å)