8TBE
Co-crystal structure of SARS-CoV-2 Mpro with Pomotrelvir
Summary for 8TBE
Entry DOI | 10.2210/pdb8tbe/pdb |
Descriptor | 3C-like proteinase nsp5, Pomotrelvir bound form (3 entities in total) |
Functional Keywords | main protease, viral protein, 3cl protease |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 68567.00 |
Authors | Olland, A.,Fontano, E.,White, A. (deposition date: 2023-06-28, release date: 2023-08-09, Last modification date: 2023-11-22) |
Primary citation | Tong, X.,Keung, W.,Arnold, L.D.,Stevens, L.J.,Pruijssers, A.J.,Kook, S.,Lopatin, U.,Denison, M.,Kwong, A.D. Evaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions. Antimicrob.Agents Chemother., 67:e0084023-e0084023, 2023 Cited by PubMed: 37800975DOI: 10.1128/aac.00840-23 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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