8TAU

APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB

8TAU の概要

• エントリーDOI: 10.2210/pdb8tau/pdb
• EMDBエントリー: 41142
• 分子名称: Anaphase-promoting complex subunit 1, Cell division cycle protein 16 homolog, Anaphase-promoting complex subunit 10, ... (19 entities in total)
• 機能のキーワード: e3 ring ligase, ubiquitin ligase, apc/c, anaphase-promoting complex-cyclosome, cell cycle, cullin-ring ligase, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 23
• 化学式量合計: 1239324.22

構造登録者

Bodrug, T.,Welsh, K.A.,Bolhuis, D.L.,Paulakonis, E.,Martinez-Chacin, R.C.,Liu, B.,Pinkin, N.,Bonacci, T.,Cui, L.,Xu, P.,Roscow, O.,Amann, S.J.,Grishkovskaya, I.,Emanuele, M.J.,Harrison, J.S.,Steimel, J.P.,Hahn, K.M.,Zhang, W.,Zhong, E.,Haselbach, D.,Brown, N.G. (登録日: 2023-06-27, 公開日: 2023-09-27, 最終更新日: 2023-12-13)

• 主引用文献: Bodrug, T.,Welsh, K.A.,Bolhuis, D.L.,Paulakonis, E.,Martinez-Chacin, R.C.,Liu, B.,Pinkin, N.,Bonacci, T.,Cui, L.,Xu, P.,Roscow, O.,Amann, S.J.,Grishkovskaya, I.,Emanuele, M.J.,Harrison, J.S.,Steimel, J.P.,Hahn, K.M.,Zhang, W.,Zhong, E.D.,Haselbach, D.,Brown, N.G.; Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).; Nat.Struct.Mol.Biol., 30:1663-1674, 2023; PubMed: 37735619; DOI: 10.1038/s41594-023-01105-5

実験手法

ELECTRON MICROSCOPY (3.5 Å)