8TA0

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881

Summary for 8TA0

• Entry DOI: 10.2210/pdb8ta0/pdb
• Descriptor: Dihydrofolate reductase, 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, dihydrofolate reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium ulcerans
• Total number of polymer chains: 1
• Total formula weight: 20217.50

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2023-06-26, release date: 2024-08-28)

• Primary citation: Woodward, E.L.,Lovell, S.,Mian, M.R.,Seibold, S.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881; To be published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)