8TA0

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881

8TA0 の概要

• エントリーDOI: 10.2210/pdb8ta0/pdb
• 分子名称: Dihydrofolate reductase, 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: ssgcid, structural genomics, seattle structural genomics center for infectious disease, dihydrofolate reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Mycobacterium ulcerans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20217.50

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2023-06-26, 公開日: 2024-08-28)

• 主引用文献: Woodward, E.L.,Lovell, S.,Mian, M.R.,Seibold, S.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881; To be published,

実験手法

X-RAY DIFFRACTION (1.95 Å)