8T80

Sequence specific (AATT) orientation of Hoechst molecules at two unique minor groove binding sites within a self-assembled 3D DNA lattice (4x5)

8T80 の概要

• エントリーDOI: 10.2210/pdb8t80/pdb
• 分子名称: DNA (5'-D(*GP*AP*GP*AP*AP*TP*TP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*AP*TP*TP*A)-3'), DNA (5'-D(P*CP*GP*TP*CP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*TP*GP*T)-3'), ... (7 entities in total)
• 機能のキーワード: self-assembly, dna nanotechnology, dna scaffold, crystal lattice, dna, minor groove binders, netropsin, dapi, hoechst, impypy, polyamide, host-guest
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 13738.87

構造登録者

Simmons, C.R.,MacCulloch, T.,Stephanopoulos, N.,Yan, H. (登録日: 2023-06-21, 公開日: 2023-12-20)

• 主引用文献: Simmons, C.R.,Buchberger, A.,Henry, S.J.W.,Novacek, A.,Fahmi, N.E.,MacCulloch, T.,Stephanopoulos, N.,Yan, H.; Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals.; J.Am.Chem.Soc., 145:26075-26085, 2023; PubMed: 37987645; DOI: 10.1021/jacs.3c07802

実験手法

X-RAY DIFFRACTION (2.91 Å)