8T6F

Crystal structure of human MBP-Myeloid cell leukemia 1 (Mcl-1) in complex with BRD810 inhibitor

8T6F の概要

• エントリーDOI: 10.2210/pdb8t6f/pdb
• 分子名称: Maltose/maltodextrin-binding periplasmic protein/Induced myeloid leukemia cell differentiation protein Mcl-1 Chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: inhibitor, mcl1, mbp-fusion, brd810, apoptosis
• 由来する生物種: Escherichia coli K-12; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58609.03

構造登録者

Poncet-Montange, G.,Lemke, C.T. (登録日: 2023-06-15, 公開日: 2024-06-19)

• 主引用文献: Rauh, U.,Wei, G.,Serrano-Wu, M.,Kosmidis, G.,Kaulfuss, S.,Siegel, F.,Thede, K.,McFarland, J.,Poncet-Montange, G.,Lemke, T.L.,Werbeck, N.,Nowak-Reppel, K.,Pilari, S.,Menz, S.,Ocker, M.,Kaushik, V.,Hubbard, B.,Ziegelbauer, K.,Golub, T.R.; BRD810 is a novel highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models; to be published,

実験手法

X-RAY DIFFRACTION (1.56 Å)