8T6D

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

8T6D の概要

• エントリーDOI: 10.2210/pdb8t6d/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, SULFATE ION, (3R)-1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4'-piperidin]-3-amine, ... (4 entities in total)
• 機能のキーワード: phosphatase, tumor target, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122443.69

構造登録者

Tang, Y.,Nguyen, V.,Wilbur, J.D. (登録日: 2023-06-15, 公開日: 2023-10-11, 最終更新日: 2023-10-25)

主引用文献

Taylor, A.M.,Williams, B.R.,Giordanetto, F.,Kelley, E.H.,Lescarbeau, A.,Shortsleeves, K.,Tang, Y.,Walters, W.P.,Arrazate, A.,Bowman, C.,Brophy, E.,Chan, E.W.,Deshmukh, G.,Greisman, J.B.,Hunsaker, T.L.,Kipp, D.R.,Saenz Lopez-Larrocha, P.,Maddalo, D.,Martin, I.J.,Maragakis, P.,Merchant, M.,Murcko, M.,Nisonoff, H.,Nguyen, V.,Nguyen, V.,Orozco, O.,Owen, C.,Pierce, L.,Schmidt, M.,Shaw, D.E.,Smith, S.,Therrien, E.,Tran, J.C.,Watters, J.,Waters, N.J.,Wilbur, J.,Willmore, L.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66:13384-13399, 2023

PubMed Abstract: Protein tyrosine phosphatase SHP2 mediates RAS-driven MAPK signaling and has emerged in recent years as a target of interest in oncology, both for treating with a single agent and in combination with a KRAS inhibitor. We were drawn to the pharmacological potential of SHP2 inhibition, especially following the initial observation that drug-like compounds could bind an allosteric site and enforce a closed, inactive state of the enzyme. Here, we describe the identification and characterization of (formerly RLY-1971), a SHP2 inhibitor currently in clinical trials in combination with KRAS G12C inhibitor divarasib (GDC-6036) for the treatment of solid tumors driven by a KRAS G12C mutation.

PubMed: 37774359
DOI: 10.1021/acs.jmedchem.3c00483

実験手法

X-RAY DIFFRACTION (2.4 Å)