8T59

Crystal structure of Para.09 bound to TREM2

Summary for 8T59

• Entry DOI: 10.2210/pdb8t59/pdb
• Descriptor: Para.09 heavy chain, Para.09 light chain, Triggering receptor expressed on myeloid cells 2, ... (7 entities in total)
• Functional Keywords: antibody, fab, complex, antigen, peptide binding protein, immune system-peptide binding protein complex, immune system/peptide binding protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 6
• Total formula weight: 101863.26

Authors

Wallweber, H.,Hsu, P.L. (deposition date: 2023-06-12, release date: 2024-07-31)

• Primary citation: Hsiao, Y.,Lin, Z.,Du, C.,Echeverria, A.,Wallweber, H.,Aung, T.,Alberstein, R.G.,Shang, Y.,Seeger, F.,Watkins, A.,Seshasayee, D.,Hansen, D.V.,Bolen, C.,Hsu, P.L.,Hotzel, I.; Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)