8T27

Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible)

Summary for 8T27

• Entry DOI: 10.2210/pdb8t27/pdb
• Related: 8FEB 8T1Y 8T1Z 8T24 8T26
• Descriptor: Sialidase, putative, N-acetyl-alpha-neuraminic acid, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• Functional Keywords: sialidase, neuraminidase, carbohydrate binding, virulence factor, hydrolase
• Biological source: Porphyromonas gingivalis
• Total number of polymer chains: 1
• Total formula weight: 57918.73

Authors

Clark, N.D.,Malkowski, M.G. (deposition date: 2023-06-05, release date: 2023-10-04, Last modification date: 2023-10-11)

• Primary citation: Clark, N.D.,Pham, C.,Kurniyati, K.,Sze, C.W.,Coleman, L.,Fu, Q.,Zhang, S.,Malkowski, M.G.,Li, C.; Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.; Plos Pathog., 19:e1011674-e1011674, 2023; PubMed: 37747935; DOI: 10.1371/journal.ppat.1011674

Experimental method

X-RAY DIFFRACTION (1.41 Å)