8T27

Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible)

8T27 の概要

• エントリーDOI: 10.2210/pdb8t27/pdb
• 関連するPDBエントリー: 8FEB 8T1Y 8T1Z 8T24 8T26
• 分子名称: Sialidase, putative, N-acetyl-alpha-neuraminic acid, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• 機能のキーワード: sialidase, neuraminidase, carbohydrate binding, virulence factor, hydrolase
• 由来する生物種: Porphyromonas gingivalis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57918.73

構造登録者

Clark, N.D.,Malkowski, M.G. (登録日: 2023-06-05, 公開日: 2023-10-04, 最終更新日: 2023-10-11)

• 主引用文献: Clark, N.D.,Pham, C.,Kurniyati, K.,Sze, C.W.,Coleman, L.,Fu, Q.,Zhang, S.,Malkowski, M.G.,Li, C.; Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.; Plos Pathog., 19:e1011674-e1011674, 2023; PubMed: 37747935; DOI: 10.1371/journal.ppat.1011674

実験手法

X-RAY DIFFRACTION (1.41 Å)