8T1R

Crystal structure of human CPSF73 catalytic segment in complex with compound 2

Summary for 8T1R

Entry DOI	10.2210/pdb8t1r/pdb
Descriptor	Cleavage and polyadenylation specificity factor subunit 3, 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, FE (III) ION, ... (6 entities in total)
Functional Keywords	nuclease, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	55157.17
Authors	Huang, J.,Tong, L. (deposition date: 2023-06-02, release date: 2023-11-08, Last modification date: 2024-01-31)
Primary citation	Tao, Y.,Budhipramono, A.,Huang, J.,Fang, M.,Xie, S.,Kim, J.,Khivansara, V.,Dominski, Z.,Tong, L.,De Brabander, J.K.,Nijhawan, D. Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3. Cell Chem Biol, 31:139-, 2024 Cited by PubMed: 37967558 DOI: 10.1016/j.chembiol.2023.10.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation