8T1R
Crystal structure of human CPSF73 catalytic segment in complex with compound 2
Summary for 8T1R
Entry DOI | 10.2210/pdb8t1r/pdb |
Descriptor | Cleavage and polyadenylation specificity factor subunit 3, 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, FE (III) ION, ... (6 entities in total) |
Functional Keywords | nuclease, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 55157.17 |
Authors | |
Primary citation | Tao, Y.,Budhipramono, A.,Huang, J.,Fang, M.,Xie, S.,Kim, J.,Khivansara, V.,Dominski, Z.,Tong, L.,De Brabander, J.K.,Nijhawan, D. Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3. Cell Chem Biol, 31:139-, 2024 Cited by PubMed: 37967558DOI: 10.1016/j.chembiol.2023.10.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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