8T1R

Crystal structure of human CPSF73 catalytic segment in complex with compound 2

8T1R の概要

• エントリーDOI: 10.2210/pdb8t1r/pdb
• 分子名称: Cleavage and polyadenylation specificity factor subunit 3, 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, FE (III) ION, ... (6 entities in total)
• 機能のキーワード: nuclease, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55157.17

構造登録者

Huang, J.,Tong, L. (登録日: 2023-06-02, 公開日: 2023-11-08, 最終更新日: 2024-01-31)

• 主引用文献: Tao, Y.,Budhipramono, A.,Huang, J.,Fang, M.,Xie, S.,Kim, J.,Khivansara, V.,Dominski, Z.,Tong, L.,De Brabander, J.K.,Nijhawan, D.; Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.; Cell Chem Biol, 31:139-, 2024; PubMed: 37967558; DOI: 10.1016/j.chembiol.2023.10.019

実験手法

X-RAY DIFFRACTION (2.2 Å)