8SZ3

Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 7j

8SZ3 の概要

• エントリーDOI: 10.2210/pdb8sz3/pdb
• 分子名称: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1S)-1-(5-bromopyridin-2-yl)ethyl]-3-[(2R)-3,3-dimethylbutan-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide, ... (5 entities in total)
• 機能のキーワード: acetylglucosaminyltransferase, inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94884.24

構造登録者

Sudom, A.,Min, X. (登録日: 2023-05-26, 公開日: 2023-12-06, 最終更新日: 2024-10-23)

• 主引用文献: Jackson, J.J.,Siegmund, A.C.,Bai, W.J.,Reed, A.B.,Birkholz, A.B.,Campuzano, I.D.G.,Crequer-Grandhomme, A.,Hu, R.,Modak, R.V.,Sudom, A.,Javier, N.,Sanders, C.,Lo, M.C.,Xie, F.,Cee, V.J.,Manzanillo, P.,Allen, J.G.; Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.; J.Med.Chem., 66:16120-16140, 2023; PubMed: 37988652; DOI: 10.1021/acs.jmedchem.3c01517

実験手法

X-RAY DIFFRACTION (2.32 Å)