8SYB
X-ray crystal structure of UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase from Thermus thermophilus strain HB27, D98N variant in the presence of UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid and UDP-N-acetylglucosamine at pH 9
Summary for 8SYB
Entry DOI | 10.2210/pdb8syb/pdb |
Related | 8SXV 8SXW 8SXY 8SY0 8SY9 8SYA |
Descriptor | UDP-2,3-diacetamido-2,3-dideoxy-glucuronic acid-2-epimerase, (2~{S},3~{S},4~{R},5~{R},6~{R})-4,5-diacetamido-6-[[[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxane-2-carboxylic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (6 entities in total) |
Functional Keywords | lipopolysaccharide, o-antigen, 2-epimerase, isomerase |
Biological source | Thermus thermophilus HB27 |
Total number of polymer chains | 2 |
Total formula weight | 86621.55 |
Authors | Kroft, C.W.,Thoden, J.B.,Holden, H.M. (deposition date: 2023-05-25, release date: 2023-09-13, Last modification date: 2023-10-18) |
Primary citation | Thoden, J.B.,McKnight, J.O.,Kroft, C.W.,Jast, J.D.T.,Holden, H.M. Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis. J.Biol.Chem., 299:105200-105200, 2023 Cited by PubMed: 37660908DOI: 10.1016/j.jbc.2023.105200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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