8SY7
E. coli DNA-directed RNA polymerase transcription elongation complex bound the unnatural dB-STP base pair in the active site
Summary for 8SY7
Entry DOI | 10.2210/pdb8sy7/pdb |
EMDB information | 40864 |
Descriptor | DNA-directed RNA polymerase subunit alpha, [[(2~{R},3~{S},4~{R},5~{S})-5-(4-azanyl-1-methyl-2-oxidanylidene-pyrimidin-5-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, DNA-directed RNA polymerase subunit beta, ... (11 entities in total) |
Functional Keywords | complex, unnatural base pairs, synthetic biology, transcription, transcription-dna-rna complex, transcription/dna/rna |
Biological source | Escherichia coli More |
Total number of polymer chains | 8 |
Total formula weight | 410283.88 |
Authors | |
Primary citation | Oh, J.,Shan, Z.,Hoshika, S.,Xu, J.,Chong, J.,Benner, S.A.,Lyumkis, D.,Wang, D. A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Nat Commun, 14:8219-8219, 2023 Cited by PubMed: 38086811DOI: 10.1038/s41467-023-43735-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.65 Å) |
Structure validation
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