8SXP

Crystal structure of long neurotoxin from the venom of the king cobra (3FTx-L15) in complex with Fab of broadly neutralizing antibody 95Mat5

Summary for 8SXP

• Entry DOI: 10.2210/pdb8sxp/pdb
• Descriptor: 95Mat5 Fab light chain, Long neurotoxin 2, 95Mat5 Fab heavy chain, ... (4 entities in total)
• Functional Keywords: snake toxin, antibody, toxin, toxin-immune system complex, toxin/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 54709.01

Authors

Nguyen, T.K.Y. (deposition date: 2023-05-23, release date: 2024-03-20)

• Primary citation: Khalek, I.S.,Senji Laxme, R.R.,Nguyen, Y.T.K.,Khochare, S.,Patel, R.N.,Woehl, J.,Smith, J.M.,Saye-Francisco, K.,Kim, Y.,Misson Mindrebo, L.,Tran, Q.,Kedzior, M.,Bore, E.,Limbo, O.,Verma, M.,Stanfield, R.L.,Menzies, S.K.,Ainsworth, S.,Harrison, R.A.,Burton, D.R.,Sok, D.,Wilson, I.A.,Casewell, N.R.,Sunagar, K.,Jardine, J.G.; Synthetic development of a broadly neutralizing antibody against snake venom long-chain neurotoxins; Sci Transl Med, 16:eadk1867-, 2024; PubMed: 38381847; DOI: 10.1126/scitranslmed.adk1867

Experimental method

X-RAY DIFFRACTION (2.9 Å)