8SXN

Structure of NLRP3 and NEK7 complex

Summary for 8SXN

• Entry DOI: 10.2210/pdb8sxn/pdb
• EMDB information: 40855
• Descriptor: Serine/threonine-protein kinase Nek7, NACHT, LRR and PYD domains-containing protein 3, 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ... (4 entities in total)
• Functional Keywords: nlrp3 nek7 complex, cryo-em, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 278378.58

Authors

Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S. (deposition date: 2023-05-22, release date: 2024-02-14)

• Primary citation: Yu, X.,Matico, R.E.,Miller, R.,Schoubroeck, B.V.,Grauwen, K.,Suarez, J.,Pietrak, B.,Haloi, N.,Yin, Y.,Tresadern, G.J.,Perez-Benito, L.,Lindahl, E.,Bottelbergs, A.,Oehlrich, D.,Opdenbosch, N.V.,Sharma, S.; Cryo-EM structures of NLRP3 reveal its self-activation mechanism; Nat Commun, 2024

Experimental method

ELECTRON MICROSCOPY (4.04 Å)