8SWA

Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP

Summary for 8SWA

Entry DOI	10.2210/pdb8swa/pdb
Descriptor	S-adenosylmethionine synthase isoform type-1, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	complex, 1-carbon, sam, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45580.20
Authors	Bruemmer, K.J.,Pham, V.N.,Toh, J.D.W. (deposition date: 2023-05-18, release date: 2023-11-15)
Primary citation	Pham, V.N.,Bruemmer, K.J.,Toh, J.D.W.,Ge, E.J.,Tenney, L.,Ward, C.C.,Dingler, F.A.,Millington, C.L.,Garcia-Prieto, C.A.,Pulos-Holmes, M.C.,Ingolia, N.T.,Pontel, L.B.,Esteller, M.,Patel, K.J.,Nomura, D.K.,Chang, C.J. Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism. Science, 382:eabp9201-eabp9201, 2023 Cited by PubMed: 37917677 DOI: 10.1126/science.abp9201 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.999 Å)

Structure validation