8SWA

Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP

8SWA の概要

• エントリーDOI: 10.2210/pdb8swa/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-1, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: complex, 1-carbon, sam, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45580.20

構造登録者

Bruemmer, K.J.,Pham, V.N.,Toh, J.D.W. (登録日: 2023-05-18, 公開日: 2023-11-15)

• 主引用文献: Pham, V.N.,Bruemmer, K.J.,Toh, J.D.W.,Ge, E.J.,Tenney, L.,Ward, C.C.,Dingler, F.A.,Millington, C.L.,Garcia-Prieto, C.A.,Pulos-Holmes, M.C.,Ingolia, N.T.,Pontel, L.B.,Esteller, M.,Patel, K.J.,Nomura, D.K.,Chang, C.J.; Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism.; Science, 382:eabp9201-eabp9201, 2023; PubMed: 37917677; DOI: 10.1126/science.abp9201

実験手法

X-RAY DIFFRACTION (1.999 Å)