8SW4

BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3

This is a non-PDB format compatible entry.

Summary for 8SW4

• Entry DOI: 10.2210/pdb8sw4/pdb
• EMDB information: 40797
• Descriptor: 21M20 heavy chain variable region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: germline targeting, hiv-1 env, neutralizing antibody, non-human primate antibody, cd4 binding site, fusion peptide, viral protein
• Biological source: Macaca; More
• Total number of polymer chains: 20
• Total formula weight: 412573.66

Authors

Ozorowski, G.,Torres, J.L.,Zhang, S.,Ward, A.B. (deposition date: 2023-05-17, release date: 2024-05-29, Last modification date: 2024-09-11)

• Primary citation: Caniels, T.G.,Medina-Ramirez, M.,Zhang, S.,Kratochvil, S.,Xian, Y.,Koo, J.H.,Derking, R.,Samsel, J.,van Schooten, J.,Pecetta, S.,Lamperti, E.,Yuan, M.,Carrasco, M.R.,Del Moral Sanchez, I.,Allen, J.D.,Bouhuijs, J.H.,Yasmeen, A.,Ketas, T.J.,Snitselaar, J.L.,Bijl, T.P.L.,Martin, I.C.,Torres, J.L.,Cupo, A.,Shirreff, L.,Rogers, K.,Mason, R.D.,Roederer, M.,Greene, K.M.,Gao, H.,Silva, C.M.,Baken, I.J.L.,Tian, M.,Alt, F.W.,Pulendran, B.,Seaman, M.S.,Crispin, M.,van Gils, M.J.,Montefiori, D.C.,McDermott, A.B.,Villinger, F.J.,Koup, R.A.,Moore, J.P.,Klasse, P.J.,Ozorowski, G.,Batista, F.D.,Wilson, I.A.,Ward, A.B.,Sanders, R.W.; Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.; Sci Immunol, 9:eadk9550-eadk9550, 2024; PubMed: 39213338; DOI: 10.1126/sciimmunol.adk9550

Experimental method

ELECTRON MICROSCOPY (2.85 Å)