8SVY

MBP-Mcl1 in complex with ligand 10

Summary for 8SVY

Entry DOI	10.2210/pdb8svy/pdb
Related PRD ID	PRD_900001
Descriptor	Maltose/maltodextrin-binding periplasmic protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, signaling protein
Biological source	Escherichia coli More
Total number of polymer chains	1
Total formula weight	58739.84
Authors	Miller, B.R.,Shaffer, P. (deposition date: 2023-05-17, release date: 2023-08-09, Last modification date: 2024-05-22)
Primary citation	Demin, S.,Peschiulli, A.,Velter, A.I.,Vos, A.,De Boeck, B.,Miller, B.,Rombouts, F.J.R.,Reuillon, T.,Lento, W.,Blanco, M.D.,Jouffroy, M.,Steyvers, H.,Bekkers, M.,Altrocchi, C.,Pietrak, B.,Koo, S.J.,Szewczuk, L.,Attar, R.,Philippar, U. Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1. Acs Med.Chem.Lett., 14:955-961, 2023 Cited by PubMed: 37465311 DOI: 10.1021/acsmedchemlett.3c00141 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation