8SVY
MBP-Mcl1 in complex with ligand 10
Summary for 8SVY
Entry DOI | 10.2210/pdb8svy/pdb |
Related PRD ID | PRD_900001 |
Descriptor | Maltose/maltodextrin-binding periplasmic protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, signaling protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 1 |
Total formula weight | 58739.84 |
Authors | Miller, B.R.,Shaffer, P. (deposition date: 2023-05-17, release date: 2023-08-09, Last modification date: 2024-05-22) |
Primary citation | Demin, S.,Peschiulli, A.,Velter, A.I.,Vos, A.,De Boeck, B.,Miller, B.,Rombouts, F.J.R.,Reuillon, T.,Lento, W.,Blanco, M.D.,Jouffroy, M.,Steyvers, H.,Bekkers, M.,Altrocchi, C.,Pietrak, B.,Koo, S.J.,Szewczuk, L.,Attar, R.,Philippar, U. Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1. Acs Med.Chem.Lett., 14:955-961, 2023 Cited by PubMed: 37465311DOI: 10.1021/acsmedchemlett.3c00141 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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