8SVY

MBP-Mcl1 in complex with ligand 10

8SVY の概要

• エントリーDOI: 10.2210/pdb8svy/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose/maltodextrin-binding periplasmic protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: myeloid cell leukemia 1, mcl-1, b-cell lymphoma 2, bcl-2, bh3 mimetic, protein-protein interaction, modulator, apoptosis, cancer, leukemia, myeloma, lymphoma, signaling protein
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58739.84

構造登録者

Miller, B.R.,Shaffer, P. (登録日: 2023-05-17, 公開日: 2023-08-09, 最終更新日: 2024-05-22)

• 主引用文献: Demin, S.,Peschiulli, A.,Velter, A.I.,Vos, A.,De Boeck, B.,Miller, B.,Rombouts, F.J.R.,Reuillon, T.,Lento, W.,Blanco, M.D.,Jouffroy, M.,Steyvers, H.,Bekkers, M.,Altrocchi, C.,Pietrak, B.,Koo, S.J.,Szewczuk, L.,Attar, R.,Philippar, U.; Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.; Acs Med.Chem.Lett., 14:955-961, 2023; PubMed: 37465311; DOI: 10.1021/acsmedchemlett.3c00141

実験手法

X-RAY DIFFRACTION (1.47 Å)