8SVG
Ubiquitin variant i53 in complex with 53BP1 Tudor domain
Summary for 8SVG
Entry DOI | 10.2210/pdb8svg/pdb |
Descriptor | Tumor protein p53 binding protein 1, Ubiquitin variant i53 (3 entities in total) |
Functional Keywords | inhibitor, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 22576.67 |
Authors | Holden, J.K.,Partridge, J.R.,Wibowo, A.S.,Mulichak, A. (deposition date: 2023-05-16, release date: 2024-03-27, Last modification date: 2024-04-03) |
Primary citation | Perez-Bermejo, J.A.,Efagene, O.,Matern, W.M.,Holden, J.K.,Kabir, S.,Chew, G.M.,Andreoletti, G.,Catton, E.,Ennis, C.L.,Garcia, A.,Gerstenberg, T.L.,Hill, K.A.,Jain, A.,Krassovsky, K.,Lalisan, C.D.,Lord, D.,Quejarro, B.J.,Sales-Lee, J.,Shah, M.,Silva, B.J.,Skowronski, J.,Strukov, Y.G.,Thomas, J.,Veraz, M.,Vijay, T.,Wallace, K.A.,Yuan, Y.,Grogan, J.L.,Wienert, B.,Lahiri, P.,Treusch, S.,Dever, D.P.,Soros, V.B.,Partridge, J.R.,Seim, K.L. Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15:2625-2625, 2024 Cited by PubMed: 38521763DOI: 10.1038/s41467-024-46816-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.21 Å) |
Structure validation
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