8SU8

Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde).

8SU8 の概要

• エントリーDOI: 10.2210/pdb8su8/pdb
• 分子名称: Krev interaction trapped protein 1, Ras-related protein Rap-1b, (6P)-6-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, ... (6 entities in total)
• 機能のキーワード: complex, inhibitor, cell adhesion
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56822.19

構造登録者

Bruystens, J.G.H. (登録日: 2023-05-11, 公開日: 2023-12-06)

• 主引用文献: Francisco, K.R.,Bruystens, J.,Varricchio, C.,McCurdy, S.,Wu, J.,Lopez-Ramirez, M.A.,Ginsberg, M.,Caffrey, C.R.,Brancale, A.,Gingras, A.R.,Hixon, M.S.,Ballatore, C.; Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors.; Acs Pharmacol Transl Sci, 6:1651-1658, 2023; PubMed: 37974623; DOI: 10.1021/acsptsci.3c00156

実験手法

X-RAY DIFFRACTION (2.01 Å)