8STI

human STING with agonist XMT-1616

8STI の概要

• エントリーDOI: 10.2210/pdb8sti/pdb
• 分子名称: Stimulator of interferon genes protein, 3-[(2E)-4-{5-carbamoyl-2-[(4-ethyl-2-methyl-1,3-oxazole-5-carbonyl)amino]-7-(3-hydroxypropoxy)-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(4-ethyl-2-methyl-1,3-oxazole-5-carbonyl)amino]-3H-imidazo[4,5-b]pyridine-6-carboxamide (3 entities in total)
• 機能のキーワード: agonist, sting, immune system, immune system-agonist complex, immune system/agonist
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22242.92

構造登録者

Duvall, J.R.,Bukhalid, R.A. (登録日: 2023-05-10, 公開日: 2023-07-26, 最終更新日: 2023-08-16)

• 主引用文献: Duvall, J.R.,Thomas, J.D.,Bukhalid, R.A.,Catcott, K.C.,Bentley, K.W.,Collins, S.D.,Eitas, T.,Jones, B.D.,Kelleher, E.W.,Lancaster, K.,Protopopova, M.,Ray, S.S.,Ter-Ovanesyan, E.,Xu, L.,Yang, L.,Zurita, J.,Damelin, M.,Toader, D.,Lowinger, T.B.; Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.; J.Med.Chem., 66:10715-10733, 2023; PubMed: 37486969; DOI: 10.1021/acs.jmedchem.3c00907

実験手法

X-RAY DIFFRACTION (1.72 Å)