8ST2

The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine

8ST2 の概要

• エントリーDOI: 10.2210/pdb8st2/pdb
• EMDBエントリー: 40752 40753 40754 40755 40756 40757
• 分子名称: Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, IgG1 Kappa Light Chain, ... (9 entities in total)
• 機能のキーワード: cys-loop ligand-gated pentameric ion channels, cation-selective channel, acetylcholine, transport protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 386858.92

構造登録者

Kang, G.,Hibbs, R.E. (登録日: 2023-05-09, 公開日: 2024-02-07, 最終更新日: 2024-11-13)

主引用文献

Mazzaferro, S.,Kang, G.,Natarajan, K.,Hibbs, R.E.,Sine, S.M.
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor.
Br.J.Pharmacol., 181:1973-1992, 2024

PubMed Abstract: α4β2 nicotinic acetylcholine (nACh) receptors assemble in two stoichiometric forms, one of which is potentiated by calcium. The sites of calcium binding that underpin potentiation are not known.

PubMed: 38454578
DOI: 10.1111/bph.16321

実験手法

ELECTRON MICROSCOPY (2.94 Å)