8SRE

Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state

Summary for 8SRE

Entry DOI	10.2210/pdb8sre/pdb
EMDB information	40728 40869 40880
Descriptor	TRPM2 chanzyme, ADENOSINE-5-DIPHOSPHORIBOSE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	trpm2 chanzyme, channel-enzyme, membrane protein
Biological source	Salpingoeca rosetta
Total number of polymer chains	4
Total formula weight	682634.72
Authors	Huang, Y.,Kumar, S.,Lu, W.,Du, J. (deposition date: 2023-05-05, release date: 2024-05-15, Last modification date: 2024-10-16)
Primary citation	Huang, Y.,Kumar, S.,Lee, J.,Lu, W.,Du, J. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38773335 DOI: 10.1038/s41594-024-01316-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.52 Å)

Structure validation